IM Pregnancy & other obstetric conditions Postpartum prophylaxis: 1 syringe w/in 72 hr of delivery. Suspected fetomaternal hemorrhage (>30 mL of whole blood or 15 mL RBC): Perform fetal red cell count by an approved laboratory technique (eg, modified Kleihauer-Betke acid elution stain technique) to determine the required Ig dosage. Divide the RBC vol of the calculated fetomaternal hemorrhage by 15 mL to obtain the number of syringe or administration. If >15 mL RBC is suspected or if the dose calculation results in a fraction, administer the next higher whole number of syringe (eg, if 1.4, give 2 syringe). Antenatal prophylaxis: 1 full dose syringe administered at approx 28 wk gestation. Follow w/ another full dose, preferably w/in 72 hr following delivery, if the infant is Rh positive. Following threatened abortion at any stage of gestation w/ continuation of pregnancy; following miscarriage, abortion, or termination of ectopic pregnancy ≥13 wk gestation; following amniocentesis at either 15-18 wk gestation or during 3
rd trimester or following abdominal trauma in 2
nd or 3
rd trimester: 1 full dose. Suspected fetomaternal hemorrhage in excess of 15 mL RBC: Perform fetal red cell count by an approved laboratory technique (eg, modified Kleihauer-Betke acid elution stain technique) to determine the required Ig dosage. Divide the RBC vol of the calculated fetomaternal hemorrhage by 15 mL to obtain the number of syringe or administration. If >15 mL RBC is suspected or if the dose calculation results in a fraction, administer the next higher whole number of syringe (eg, if 1.4, give 2 syringe). Abdominal trauma, amniocentesis, or other AR requiring administration of HyperRHO S/D at 13-18 wk gestation: Give another full dose at 26-28 wk. Any case (if the baby is Rh positive): Give w/in 72 hr after delivery. May withheld postpartum dose if delivery occurs w/in 3 wk after last dose unless there is fetomaternal hemorrhage in excess of 15 mL RBC.
Transfusion of Rho(D) positive red cells to Rho(D) negative recipient Multiply the vol of Rh positive whole blood administered by the hematocrit of the donor unit giving the vol of RBC transfused. Divide RBC vol by 15 mL which provides the number of syringes to be administered. If the dose calculation results in a fraction, administer the next higher whole number of syringe (eg, if 1.4, give 2 syringe). Administer preferably as soon as possible or w/in 72 hr after incompatible transfusion.